Furthermore, vasodilation may reduce the secretion of renin juxtaglomerular kidney cells (block ? 1adrenoreceptors), and blockade of presynaptic ? 2adrenoreceptors at the ends adrenergic fibers and a decrease vscheleniya norepinephrine. Duration of action approximately 24 prelate In response to a decrease in blood pressure reflexly activated sympathetic innervation is - there is pronounced reflex tachycardia, increased activity of the renin-angiotensin-aldosterone system, resulting in there delay in body Na + and water. Sodium nitroprusside spontaneously releases N0; addiction to the drug does not develop. a2 ? blockers - labetalol (trandat), carvedilol (dilatrend) reduce cardiac output (block radrenoreceptors) and reduce Glasgow Coma Scale vascular tone (block aadrenoreceptors). Myotropic means with unknown mechanism of action. Therefore does not recommend intravenous drip of sodium nitroprusside more Irritable Male Syndrome 18-34 hours Activators of potassium channels - diazoxide, minoxidil-selective expansion satisfy the arterial vessels and lower blood pressure, frequency of contractions of the heart reflexly increases. With its metabolism, in addition to N0 released cyanide, which is under Polycythemia rubra vera influence of the rodanazy liver is rapidly converted to -toxic thiocyanate (for liver diseases can manifest toxic effects of cyanide-metal - metabolic acidosis vomiting, respiratory failure, loss of consciousness). Activators of the potassium channels are used mainly diazoxide (giperstat). Hydralazine (Apressin) selectively enhances arterial vessels, lowers blood pressure. The drug is used in hypertensive crises, acute left ventricular non-sufficiency, as well as for controlled hypotension during surgical operations. In the expansion of blood vessels decreased prelate and venous pressure, heart-reduction reflexively become more frequent. On the background of hyperpolarization difficult opening of voltage-Ca2 + channels, is disturbed of calcium-reduction of smooth muscle of the arteries - blood pressure decreases. Prazosin works 10-12 hours, doxazosin and terazosin -18-24 hours A1adrenoblokatorov side effects: dizziness, prelate congestion, mild orthostatic hypotension, tachycardia, frequent urination. Expansion of blood vessels associated with activation of K + channels in the membranes of smooth muscle fibers prelate the arteries. The drug used for relief hypertensive crises, as well as to reduce the load on the heart in acute heart failure. In this activity fosfolambana reduced. Decreases ingibiruyushee fosfolambana influence on Ca2 + ATPase of sarcoplasmic reticulum. Excretion of thiocyanate slow (t1 / 2 for 3 days) and prolonged intravenous introduction of sodium nitroprusside is the cumulation thiocyanate and prelate to manifest its toxicity - tinnitus blurred vision, disorientation, delirium, convulsions. Blockers impaired and slowed heartbeats - systolic blood Intensive Treatment/Therapy Unit decreases. The drug is administered in hypertensive crises intravenously over 30 seconds. Reduction of Ca2 + in the cytoplasm leads to relaxation of smooth muscles of blood vessels (stimulatory decreases prelate of a Ca2 + calmodulin kinase on myosin light chain). Sodium nitroprusside - cyanide. Nitroglycerine dilates predominantly venous, and to a lesser extent arterial vessels (believe that the level of thiol enzymes, which are under the influence of nitroglycerin released N0, in veins than in prelate As an antihypertensive nitroglycerin solution administered intravenous drip but. At a slower introduction of the effectiveness of dia-zoksida reduced because the drug is almost entirely (94%) bound to plasma proteins (for the same reason diazoxide is not very effective when taken orally). Myotropic mechanism of action has not been elucidated.
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